Dr. Daniele Hasler, Scientist, RNA Process Development, BioNTech SE

Dr. Daniele Hasler is an RNA biologist with more than a decade of experience spanning fundamental RNA research and the development of GMP-compliant manufacturing processes for mRNA therapeutics. He obtained his PhD in Biochemistry from the University of Regensburg, Germany, where he dissected mechanistic pathways of microRNA biogenesis. He subsequently continued his work on RNA-binding proteins and their roles in human disease, securing independent funding to investigate RNA modifications and contributing to academic teaching and mentoring.

In 2023, Daniele joined BioNTech SE in Mainz as a Scientist in RNA Process Development. In this role, he drives the optimization of in vitro transcription processes for the GMP-compliant production of mRNA therapeutics and serves as a subject matter expert for mRNA production and purification across multiple infectious disease and oncology clinical programs. Daniele applies Quality by Design principles to RNA-based drug substance development, thereby contributing to the establishment of robust and efficient manufacturing strategies. His cross-functional work within CMC programs supports the clinical development and marketing authorization of next-generation mRNA-based therapeutics.