Our History

With key capabilities in immunology, deep genomics and artificial intelligence, BioNTech is dedicated to ushering in a new era of medicine

BioNTech has taken a remarkable journey from a small, privately owned startup to a global, fully integrated biotechnology company.
Through unwavering determination, we have delivered groundbreaking scientific discoveries and profound biotechnological innovation, bringing the first mRNA medicinal product to market.
BioNTech has continuously and strategically expanded its portfolio and capabilities and is well-positioned to help transform medicine.

Business development

2025

Launch of global strategic partnership with Bristol Myers Squibb to jointly broaden and accelerate the development of our PD-L1 x VEGF-A next-generation bispecific antibody candidate.

Business development

2025

Initiation of pivotal clinical trials with our PD-L1 x VEGF-A bispecific antibody candidate in extensive-stage small cell lung cancer as well as non-small cell lung cancer.

Scientific breakthroughs

2024

Initiation of pivotal clinical trials with our PD-L1 x VEGF-A bispecific antibody candidate in extensive-stage small cell lung cancer as well as non-small cell lung cancer.

Scientific breakthroughs

2024

Start of a pivotal Phase 3 clinical trial with our HER2- targeting ADC candidate in metastatic breast cancer.

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Business Development

2023

Acquisition of InstaDeep, a leading global technology company in the field of AI and machine learning, to further strengthen BioNTech’s position in AI-supported drug discovery, design and development.

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Business Development

2023

Initiation of an R&D collaboration in antibody-drug conjugates (ADCs), adding targeted therapies to BioNTech’s portfolio.

Business Development

2023

Launch of a strategic partnership with the Government of the United Kingdom aiming to accelerate the development of personalized mRNA cancer immunotherapies and make them available to up to 10,000 patients by the end of 2030, either in clinical trials or as authorized treatments.

Business Development

2022

Introduction of BioNTainer modules to enable scalable manufacturing of mRNA-based medicines worldwide. Today, BioNTech is building BioNTainer-based facilities in Kigali, Rwanda and Melbourne, Australia.

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Business Development

2022

Development and commercialization of first variant-adapted COVID-19 vaccine.

Scientific breakthroughs

2020

With the emerging pandemic, BioNTech starts the development of a COVID-19 vaccine based on decades of technological advancement and research and development in the field of mRNA therapies, an endeavor called Project Lightspeed.

Within 10 months, the Pfizer-BioNTech COVID-19 vaccine was developed, evaluated in large clinical trials and received (emergency or conditional) approvals from authorities in multiple

different countries and regions. This was not only the fastest vaccine development against a new pathogen in medical history, but also proof of concept for mRNA as a new drug class in medicine.

Business Development

2019

BioNTech becomes a publicly traded company on the NASDAQ Global Select Market under the ticker symbol BNTX.

Business Development

2015

Portfolio expansion through first R&D collaboration in next-generation immunomodulators. Today, BioNTech works together with Duality Biologics, Genentech, a member of the Roche group, Genevant, Genmab, OncoC4, Regeneron, Pfizer, and others.

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Scientific breakthroughs

2014

Start of a first-in-human clinical trial with an individualized mRNA cancer immunotherapy approach in solid tumors designed by leveraging BioNTech’s ML-trained algorithms. Results were published in Nature in 2017.

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Scientific Breakthroughs

2012

Initiation of a first-in-human clinical trial with a personalized mRNA cancer immunotherapy candidate. Results were published in Nature in 2020.

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Business Development

2008

BioNTech is founded by Prof. Ugur Sahin, M.D., Prof. Özlem Türeci, M.D., and Prof. Christoph Huber, M.D., to realize their vision of translating scientific discoveries into life-saving treatments. The company’s founding involved seed financing of $180 million from Andreas and Thomas Strüngmann, the MIG funds headed by Michael Motschmann, and Helmut Jeggle.

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Scientific breakthroughs

Mid-1990s

mRNA was overlooked by most researchers for decades because it was considered too unstable for drug development due to the challenges of delivering it to the right cells and achieving adequate immune responses. Defying conventional beliefs, BioNTech co-founders, Prof. Ugur Sahin, M.D., and Prof. Özlem Türeci, M.D., begin researching mRNA technology early on and achieve a series of scientific and technological breakthroughs to harness the molecule’s potential, culminating in the development of the first mRNA drug approved for human use more than 20 years later.

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