Our Collaborators

Joining forces to improve health worldwide

Our work at BioNTech is driven by data and a clear vision: To translate science into first-in-class and best-in-class medicines for people worldwide. We endeavor to usher in a new era of immunotherapy to address cancer, infectious diseases, as well as a growing list of other serious conditions. In our journey to deliver therapies for a healthier tomorrow, we have successfully established a network of world-class corporate and scientific partnerships.

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If your team is interested in collaborating with us, please contact us to learn about partnering and collaboration opportunities.

Our Collaborators

Alongside our industry-leading partners, we work on bringing novel therapies to the patients who need them most.

Partnered Programs

Bill & Melinda Gates Foundation

In September 2019, we entered into a partnership with the Bill & Melinda Gates Foundation to develop HIV and tuberculosis programs based on our proprietary mRNA vaccine technology. The investment was the largest equity investment made by the Foundation’s Strategic Investment Fund to date.  The collaboration comprises identification and pre-clinical development of vaccines and immunotherapies for these infectious diseases and strives to provide affordable access to world-class medicines in developing countries. The collaboration may also be extended to other infectious disease indications.

Our mRNA vaccine platform

Crescendo Biologics

In January 2022, we entered into a multi-target discovery collaboration with Crescendo Biologics to develop novel immunotherapies for the treatment of patients with cancer and other diseases. Utilizing Crescendo’s proprietary Humabody® VH platform, we aim to develop precision immunotherapies, including mRNA-based antibodies and engineered cell therapies against select targets. Their specific properties and modular structure makes Humabodies ideally suited for the development of multi-target immunotherapies.

Click here for more information on our antibody and cell therapy platforms.

Duality Biologics

In April 2023, we formed a global strategic partnership with Duality Biologics to accelerate the development of differentiated antibody-drug conjugate (ADC) therapeutics for solid tumors. This agreement further expands our clinical-stage oncology portfolio with a new class of precision medicine therapeutics expanding the breadth of our immunotherapy toolkit with synergistic potential. As part of the collaboration, we will gain access to two topoisomerase-1 inhibitor-based ADC candidates out of Duality Biologics' pipeline: DB-1303 and DB-131. Duality Biologics’ lead candidate, DB-1303, is directed against Human Epidermal Growth Factor Receptor 2 (HER2), a target that is overexpressed in a variety of cancers and contributes to the aggressive growth and spread of cancer cells. DB-1303 received Fast Track designation from the U.S. Food and Drug Administration (“FDA”) and is currently in a Phase 2 clinical trial for HER2-expressing advanced solid tumors. 

For more information on our ADC platform, click here.

Fosun Pharma

On 16 March 2020, BioNTech and Fosun Pharma announced a strategic collaboration to develop and commercialize COVID-19 vaccines based on BioNTech’s mRNA technology platform for the Greater China Market including the Chinese Mainland, Hong Kong SAR, Macau SAR and Taiwan region. The mRNA COVID-19 vaccine has been granted Emergency Use Application in Hong Kong SAR (January 2021) and Special Import Authorizations in Macau SAR (February 2021) and the Taiwan region (July 2021) and in December 2022, we provided approximately 11,500 COVID-19 vaccine doses to enable a vaccination campaign for German expatriates in Mainland China.

For more information on our mRNA vaccine platform, click here.


In September 2016, we embarked on a pioneering collaboration with Genentech, a member of the Roche group, to jointly research, develop, manufacture and commercialize individualized mRNA-based vaccines targeting cancer neoantigens specific to individual patients: individualized Neoantigen Specific Immunotherapy (iNeST). This effort includes our iNeST development candidate autogene cevumeran BNT122, which is currently being evaluated in two jointly-conducted clinical trials for advanced melanoma and advanced/metastatic solid tumors, respectively. Under the partnership, BioNTech also began a colorectal cancer Phase 2 trial in October 2021 which utilizes an individualized approach.

For more information on our mRNA-based iNeST platform, click here.


In July 2018, we formed a strategic partnership with Genevant for the development of certain mRNA-based protein replacement therapies. The collaboration also includes certain exclusive licenses to Genevant’s lipid nanoparticle (LNP) drug delivery technology for mRNA-based products directed to specified oncology targets.

For more information on our protein replacement platform for rare diseases, click here.


In May 2015, we entered into a license and collaboration agreement with Genmab to jointly research, develop and commercialize novel mono- and bispecific cancer antibodies with superior in vivo efficacy, fusing our proprietary immunomodulatory antibodies and Genmab’s DuoBody® technology platform or HexaBody® technology platform. The collaboration was expanded in 2016 to include additional targets and technologies as well as in 2022 to include novel monospecific antibody candidates for various cancer indications.

Our first joint product candidate, BNT311/GEN 1046, entered clinical testing in solid tumors in June 2019 and is currently being evaluated in two additional clinical trials for the treatment of advanced solid tumors and non-small cell lung cancer (NSCLC). Our second jointly developed candidate, BNT312/GEN1042, entered clinical evaluation for the treatment of metastatic or locally advanced solid tumors in September 2019.

For more information on our next-generation checkpoint immunomodulators platform, click here.


In February 2022, we entered into a 3-year, multi-target research collaboration with Medigene to develop T cell receptor (TCR) based immunotherapies against cancer. Medigene’s automated, high-throughput TCR discovery platform will be leveraged to discover and develop innovative TCR immunotherapies against solid tumor targets selected by BioNTech. The agreement includes the acquisition of Medigene’s next generation preclinical PRAME TCR program and licenses to their PD1-41BB switch receptor and precision pairing technologies.  

For more information on our TCR platform, click here.


In March 2023, we entered into a license and collaboration agreement to co-develop and commercialize OncoC4’s next-generation anti-CTLA-4 monoclonal antibody candidate, ONC-392, as monotherapy or combination therapy in various cancer indications. In addition, we also plan to combine ONC-392 with our proprietary oncology product candidates to evaluate complementary modes of action with the aim to increase therapeutic effect and unlock larger patient populations. For more information on our next-generation checkpoint immunomodulators platform, click here.


Together with our partner Pfizer, we developed the first FDA approved mRNA-based vaccine and the first COVID-19 vaccine in history, in an unprecedented development timeline. The renowned success of our COVID-19 collaboration, initiated in March 2020, was built on the strength of our existing partnership for the development of a mRNA-based influenza vaccine (BNT161) announced in August 2018. To expand the infectious disease partnership, we signed a development and commercialization collaboration with Pfizer to develop the first mRNA-based vaccine for the prevention of shingles (herpes zoster virus, or HZV).

For more information on our mRNA vaccine platform, click here.


In July 2020, we began a strategic collaboration with Regeneron to jointly conduct a Phase 2 clinical trial combining our proprietary mRNA-based FixVac vaccine candidate, BNT111, and Libtayo® (cemiplimab), an anti-PD-1 therapy for the treatment of advanced melanoma jointly developed by Regeneron and Sanofi. The Phase 2 trial was initiated in June 2021 and BNT111 received Orphan Drug Designation by the FDA and FDA Fast Track Designation later that same year. 

In March 2022, we announced the expansion of our strategic collaboration with Regeneron. Under the agreement, the combination of our FixVac product candidate BNT116 and Libtayo is expected to be advanced into clinical development for the treatment of advanced non-small-cell lung cancer (NSCLC). The first-in-human clinical trial is intended to evaluate the safety, tolerability and preliminary efficacy of BNT116 alone and in combination with Libtayo. 

For more information on our mRNA-based FixVac platform, click here.

Ryvu Therapeutics

In November 2022, we entered into a multi-target research collaboration with Ryvu Therapeutics for several small molecule immunotherapy programs as well as an exclusive license agreement for Ryvu’s STING agonist portfolio as standalone small molecules. The collaboration consists of two parts: BioNTech has a global, exclusive license to develop and commercialize Ryvu’s STING agonist portfolio as standalone small molecules, including as monotherapy and in therapeutic combinations. In addition, BioNTech and Ryvu jointly undertake drug discovery and research projects to develop multiple small molecule programs directed at exclusive targets selected by BioNTech, primarily focused on immune modulation within oncology, with potential applications in other disease areas.

For more information on our small molecule immunomodulators, click here.


In November 2015, we announced a licensing, co-development and co-commercialization agreement with Sanofi for intratumorally administered mRNA-based therapeutics for the treatment of solid tumors. In March 2018, Sanofi selected the product candidate, BNT131/SAR441000, which encodes several immunomodulators cytokines, for further development . We have exercised our option for co-development and co-commercialization of this candidate, which entered the clinic in January 2019.

For more information on our mRNA-based intratumoral immunotherapy platform, click here.


In June 2015, we initiated a strategic partnership with Siemens to construct a fully automated, paperless and digitalized commercial cGMP-production site for individualized vaccines. The partnership was expanded in response to the COVID-19 vaccine program as Siemens supported the rapid upscaling of production capacities in our Marburg facility, which is now a model for new manufacturing sites around the world.

For more information on our comprehensive manufacturing capabilities, click here.

Scientific Collaborations

BioNTech collaborates with a large number of universities and medical centers in Europe and the U.S. to discover and develop new immunotherapies.


Ci3 is a scientific, clinical and regulatory network of over 500 scientists committed to advancing “new to the world” immunotherapies.


The DZIF (German Center for Infection Research) aims to bridge the gaps between the discovery of new treatment approaches, preclinical development and clinical testing.


TRON is a biopharmaceutical research organization that pursues the development of new diagnostics and drugs to treat cancer and other severe diseases. TRON was founded to facilitate clinical translation of innovative science by interfacing between public and private stakeholders and bridging the gap between research insight and mature product development.

University of Pennsylvania

In October 2018, we entered into a research collaboration with the University of Pennsylvania that provides us with the exclusivity to develop and commercialize mRNA immunotherapies for the treatment of up to 10 infectious disease indications with BNT163 entering the clinic in in December 2022. BNT163 is an HSV vaccine candidate for the prevention of genital lesions caused by HSV-2 and potentially HSV-1.

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